Piperazine → HCID 13307194, compound

Participants

Reaction Steps

10 g of 2-chloro-4-pyrrolidino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine, 10 g of piperazine and 50 ml of benzene were heated at a bath temperature of 70°-80° C. for 4 hours. The solvent was then distilled off and the resulting residue was dissolved in dichloromethane. The solution was washed with water and dried. The solvent was distilled off and the resulting crystals were washed thoroughly with diethyl ether to obtain 7.3 g (61% yield) of 2-piperazino-4-pyrrolidino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine.

Provenance & Evidence