Potassium Hydroxide → HCID 178503518, compound

Participants

Reaction Steps

20 g of ethyl 3-oxotetrahydrothiopyran-2-carboxylate was added to 120 ml of a methanolic solution containing 9 g of potassium hydroxide at room temperature while stirring. Then, a small amount of S-methylisothiourea hydrobromide was added to the mixture and the stirring was continued for 2 hours. The reaction solution was then poured into ice-water, and the mixture was made acidic with acetic acid. The precipitated crystals were separated by filtration and recrystallized from acetic acid to obtain 4-hydroxy-2-methylthio-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine as colorless needles having a melting point of 248° C.

Provenance & Evidence