1-Methylpiperazine → HCID 13307200, compound

Participants

Reaction Steps

A mixture of 6.5 g of 2-chloro-4-morpholino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine and 15 ml of N-methylpiperazine was heated at a bath temperature of 70° to 80° C. for 3 hours. After cooling, the reaction solution was extracted with chloroform, and the extract was washed with water and dried. The solvent was distilled off and the resulting crystals were recrystallized from a mixture of dichloromethane-n-hexane to obtain 5.5 g (69% yield) of 2-(N-methylpiperazino)-4-morpholino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine as colorless needles having a melting point of 100° C.

Provenance & Evidence