Benzyl Chloride → HCID 13307202, compound

Participants

Reaction Steps

1.6 g of benzyl chloride was added dropwise to a mixture of 3 g of 4-morpholino-2-piperazino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine, 4 g of potassium carbonate and 30 ml of N,N-dimethylformamide at room temperature under stirring, followed by stirring for 5 hours. The reaction solution was extracted with ethyl acetate, and the extract was washed with water and dried. The solvent was then distilled off and the resulting crystals were recrystallized from a mixture of diethyl ether-petroleum ether to obtain 3.1 g (82% yield) of 2-(N-benzylpiperazino)-4-morpholino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine as pale yellow prisms having a melting point of 125° C.

Provenance & Evidence