反应详情

In 4.5 ml of methanol were dissolved 151 mg of 2-amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4-one (dihydrochloride) and 138 mg of 1,5-dibromopentane, followed by addition of 2.4 ml of 1 N-sodium hydroxide. The mixture was stirred at room temperature for 4 days. The solvent was then distilled off under pressure and the residue was purified by silica gel column chromatography. The fractions containing the desired compound were pooled and after addition of an excess of hydrogen chloride/ethanol, concentrated to dryness, followed by precipitation with ether to give 45 mg of the desired compound.

1. distillationThe solvent was then distilled off under pressure
2. customthe residue was purified by silica gel column chromatography
3. additionThe fractions containing the desired compound
4. additionafter addition of an excess of hydrogen chloride/ethanol
5. concentrationconcentrated to dryness
6. customfollowed by precipitation with ether