HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → H-Cys(MBzl)-Thr-ol trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Thioanisole | HCID 7520 | — |
| Reactant | BOC-Cys(MBzl)-Thr-ol | HCID 131713414 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | H-Cys(MBzl)-Thr-ol trifluoroacetate | HCID 131713415 | — |
Reaction Steps
7.1 g BOC-Cys(MBzl)-Thr-ol and 5 ml thioanisole are dissolved in 25 ml methylene chloride. The solution is added to 50 ml TFA and allowed to stand for 20 minutes at room temperature. The mixture is diluted with ca. 1.5 liters ethyl-ether and the precipitated product filtered off and dried to yield the title compound:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435385 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-bc77261974d2451e85c3866ef5f256dc |
| Source note | uspto-grants-1984_03 |