HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[5-(1,1-dimethylethyl)-6H-1,3,4-thiadiazin-2-yl]-2,6-dimethoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Dimethoxybenzoyl chloride | HCID 74810 | — |
| Reactant | 2-amino-5-(1,1-dimethylethyl)-6H-1,3,4-thiadiazine | HCID 13268203 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-[5-(1,1-dimethylethyl)-6H-1,3,4-thiadiazin-2-yl]-2,6-dimethoxybenzamide | HCID 13268205 | 12.8% |
Reaction Steps
To a solution of 1.71 g of 2-amino-5-(1,1-dimethylethyl)-6H-1,3,4-thiadiazine and 1.01 g triethylamine in 18 ml dioxane was added 2.11 g of 2,6-dimethoxybenzoyl chloride. The reaction mixture was stirred at room temperature for 3 hours and poured into 100 ml water. The solid was collected and recrystallized from ethanol. The second crop of material provided 0.43 g of N-[5-(1,1-dimethylethyl)-6H-1,3,4-thiadiazin-2-yl]-2,6-dimethoxybenzamide. mp=175°-177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04436549 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-09556581192342388446d0af43de30dd |
| Source note | uspto-grants-1984_03 |