Isopropylamine → HCID 20467337, compound

Participants

Reaction Steps

5.2 g (25 mM) 4-(2,3-epoxypropyloxy)-2,1,3-benzthiadiazole in 60 ml. dioxan were heated under reflux for 4 hours with 30 ml. isopropylamine. The reaction mixture was then evaporated and the residue was chromatographed on a silica gel column (silica gel particle size 0.063-0.200 mm., elution agent methanol with a small addition of glacial acetic acid). The residue obtained after evaporation of the eluted fractions was recrystallized from diisopropyl ether. There were obtained 4.1 g (62% of theory) 4-(3-isopropylamino-2-hydroxy-propyloxy)-2,1,3-benzthiadiazole, which had a melting point of 100°-102° C.

Provenance & Evidence