HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 21-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 21-(2-Hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoic acid | HCID 12824071 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 21-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoate | HCID 12824097 | — |
Reaction Steps
To a solution of 3 g of the above 21-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoic acid in 10 ml of methanol is added p-toluenesulfonic acid (30 mg), followed by heating under reflux for 2 hours. After cooling to room temperature, water is added and the mixture is stirred at 0° C. to give colorless crystals of methyl 21-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoate. m.p. 72°-72.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04436753 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-f6c8c053b7e249c18e342c075fef6f40 |
| Source note | uspto-grants-1984_03 |