HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Ethyl[(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6,7-Dichloro-1-benzothiophene-5-ol | HCID 13289997 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl[(6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate | HCID 13289999 | 63.8% |
Reaction Steps
A mixture of 3.6 g of 6,7-dichloro-5-hydroxybenzo[b]thiophene, 3.0 g of ethyl bromoacetate, 1.5 g of potassium carbonate and 40 ml of anhydrous dimethylformamide is stirred at 70°-80° for 16 hours. The cooled mixture is diluted with ice-water (200 g) and the solid collected by filtration. Recrystallization of the crude product from acetone-hexane gives 3.2 g of ethyl[ (6,7-dichlorobenzo[b]thien-5-yl)oxy]acetate as yellowish needles, mp 92°-93°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04436748 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-bbc41addb75f4493912826c2b1088264 |
| Source note | uspto-grants-1984_03 |