反应详情

温度

0 °C

α-Hydroxypalmiticacid (3.2 g) was dissolved in pridine (15 ml), and palmitoyl chloride (3.3 g) was added thereto under stirring at 0° C. The resulting mixture was allowed to stand over night at room temperature. The reaction mixtue was poured into water and the aqueous solution was stirred at room temperature for 1 hour, followed by acidification with 1 N hydrochloric acid solution, and extraction with ethyl acetate. The extract was washed with water, dried over magnesium sulfate and concentrated to give a residue which was recrystallized from petroleum ether to afford crystals of 2-hexadecanoyloxyhexadecanoic acid (5.4 g). M.p. 55° to 56° C.

1. additionwas added
2. waitto stand over night at room temperature
3. stirringthe aqueous solution was stirred at room temperature for 1 hour
4. extractionfollowed by acidification with 1 N hydrochloric acid solution, and extraction with ethyl acetate
5. washThe extract was washed with water
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated
8. customto give a residue which
9. customwas recrystallized from petroleum ether