Alanylthreonine → HCID 54374028, compound

HRID 1903536Notes

Reaction equation

[C:1]([O:18][CH:19]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH2:20][C:21]([OH:23])=O)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[NH2:39][C@H:40]([C:42]([NH:44][C@H:45]([C:49]([OH:51])=[O:50])[C@@H:46]([CH3:48])[OH:47])=[O:43])[CH3:41]>>[C:1]([O:18][CH:19]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH2:20][C:21]([NH:39][C@H:40]([C:42]([NH:44][C@H:45]([C:49]([OH:51])=[O:50])[C@@H:46]([CH3:48])[OH:47])=[O:43])[CH3:41])=[O:23])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

Reactant 2

HCID 6427004Alanylthreonine

HCID 134890283-Hexadecanoyloxyoctadecanoic acid

Product 1

HCID 54374028HCID 54374028, compoundYield 82.9%

Procedure

Starting from 3-hexadecanoyloxyoctadecanoic acid (150 mg) prepared by the method described in Preparation 2(3) and N-L-alanyl-L-threonine (303 mg), N-[N-(3-hexadecanoyloxyoctadecanoyl)-L-alanyl]-L-threonine (164 mg) was obtained as powder according to similar manner to that of Example 12.

Workup

customprepared by the method

Sources & evidence

ORD record: ord-9d4a2271fc244826a5dd903ca021757e
Source dataset: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04436726

Reaction notes

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