2,3-Dichlorobenzoyl chloride → HCID 20242181, compound

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Reaction Steps

2.88 g of 4-phenylimidazole are dissolved in 7 ml of tetrahydrofuran; a solution of 2.12 g of dichlorobenzoyl chloride in 5 ml of tetrahydrofuran is then added, and the mixture is heated, in the course of which 4-phenylimidazole hydrochloride precipitates. The mixture is diluted with 15 ml of tetrahydrofuran, and is filtered at room temperature in vacuo. The filtrate is subsequently evaporated to dryness in a rotary evaporator, and the residue is recrystallised from 15 ml of ethyl acetate. The yield is 1.55 g (48.9% of theory) of the desired product, m.p. 135°-136° C. By concentration of the mother liquor by evaporation and recrystallisation from 8 ml of benzene, there are obtained a further two fractions (0.76 g, m.p. 135°-136° C.; and 0.41 g, m.p. 134°-135° C.). The total yield is hence 2.72 g (85.8% of theory).

Provenance & Evidence