Dimethyl Sulfoxide → 3-(2-Benzoyl-4-chlorophenyl)prop-2-enenitrile

Participants

Reaction Steps

A mixture of 50.9 g (0.168 mol) of α,4-dichloro-2-(benzoyl)benzenepropanenitrile, 17 g (0.14 mol) of potassium carbonate, 50.9 g (0.5 mol) of potassium bicarbonate and 510 ml of dimethyl sulfoxide was stirred at room temperature for 48 hours. The mixture was diluted with 1.5 liters of water, and the resulting precipitate was collected by filtration. Recrystallization from a mixture of methylene chloride and ether gave off-white prisms, mp 89°-91° C.

Provenance & Evidence