HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 13246740, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | Cyclohexylurea | HCID 69684 | — |
| Reactant | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester | HCID 98424 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13246740 | HCID 13246740 | — |
Reaction Steps
15.1 parts by weight of methyl 3-keto-1,5-dihydrothiophene-4-carboxylate, 14.2 parts by weight of cyclohexylurea and 0.5 part by weight of p-toluenesulfonic acid in 100 parts by weight of xylene were refluxed for 4 hours in an apparatus equipped with a water separator. The mixture was cooled, and the residue was then filtered off under suction and recrystallized from toluene. 20.3 parts by weight of N-cyclohexyl-N'-(3-methoxycarbonyl-2,5-dihydrothien-4-yl)-urea of melting point 154°-155° C. were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04437878 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-6095da03ae9d46f18dc7d452f0ccd07a |
| Source note | uspto-grants-1984_03 |