Methyl chloroformate → Methyl 2-bromo-4-fluorobenzoate

HRID 1903649Notes

Reaction equation

HRID 1903649 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1O.[OH-].[Na+].Cl[C:13]([O:15][CH3:16])=[O:14]>O>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:13]([O:15][CH3:16])=[O:14]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 6054722-Bromo-4-fluorophenol

Product 1

HCID 7210837Methyl 2-bromo-4-fluorobenzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 2-bromo-4-fluorophenol (28 g) in a solution of sodium hydroxide (7 g) in water (100 ml), methyl chloroformate was dropwise added thereto at a temperature below 10° C. The produced crystals were collected by filtration and washed with water to give methyl 2-bromo-4-fluorophenylformate (41 g). M.P., 80.7° C.

Workup

  1. customat a temperature below 10° C
  2. filtrationThe produced crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-3ec51ce3a83f45c7861d0afd0d0e340d
Source dataset
uspto-grants-1984_03
Patent number
US04437877

Reaction notes

Loading…