Dichloromethane → tert-butyl 4-fluoro-7,7-diphenyl-3,3a,4,5,6,7a-hexahydro-1H-isoindole-2-carboxylate
Reaction equation
[Cl:40][CH2:41][Cl:42].[O:1]1[CH2:2][CH2:3][N:4]([S:5]([F:6])([F:7])[F:8])[CH2:9][CH2:10]1.[c:11]1([C:17]2([c:34]3[cH:35][cH:36][cH:37][cH:38][cH:39]3)[CH2:18][CH2:19][CH:20]([OH:33])[CH:21]3[CH2:22][N:23]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:24][CH:25]23)[cH:12][cH:13][cH:14][cH:15][cH:16]1>>[F:8][CH:20]1[CH2:19][CH2:18][C:17]([c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[CH:25]2[CH:21]1[CH2:22][N:23]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:24]2Participants
4
Sources & evidence
- ORD record
- ord-36b3213bb7c046bcb3be55da44095cc8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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