Sodium Bicarbonate → HCID 86739316, compound

Participants

Reaction Steps

The formate ester (e4, 10 mg) was dissolved in 30% aqueous 1,4-dioxan (10 ml) and shaken with hydrogen in the presence of 5% palladium on carbon catalyst (15 mg) for 3.5 hours. Sodium bicarbonate (2.3 mg) was then added and the solution filtered through Celite, washing well with water (20 ml). The filtrate was concentrated at reduced pressure to approximately 15 ml and washed with ethylacetate (3×20 ml). The resulting aqueous solution was estimated to contain 2.2 mg of the title compound (e7) based on εm 14,000 at λmax 307 nm in the uv spectrum,λmax (H2O) 307 nm 229 nm.

Provenance & Evidence