HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → HCID 12941343, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Benzene | HCID 241 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Bromothiophene-3-carbaldehyde | HCID 12284894 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Product | HCID 12941343 | HCID 12941343 | — |
Reaction Steps
A solution of 5-bromo-3-thiophenecarboxaldehyde (32.5g) in benzene (500 ml) was treated with PTSA (0.323g) and ethylene glycol (21.1g), and the mixture heated under reflux in a Dean and Stark apparatus until the theoretical volume of water had been removed. After cooling the mixture was washed with water, (2x) then brine, dried (MgSO4), filtered and concentrated, and the residue distilled (b.p. 96°-100° at 0.4 mm) to give the title compound as an oil (24 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04438111 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-0a1c996ec206469e916003eb6c47003d |
| Source note | uspto-grants-1984_03 |