Hydrochloric Acid → HCID 178488771, compound

Participants

Reaction Steps

A solution of α-formyl desoxyanisoin (21.3 g, 75 mmole) and thiourea (9.75 g, 1.7 equiv) in 375 ml ethanol was treated with 3 N HCl (7.5 ml) and heated at reflux for 3.5 hours. The reaction mixture was concentrated on the rotary evaporator and the residue recrystallized from ethanol to give the title compound (11.6 g), m.p. 188°-191°. Infrared and H-NMR spectra were consistent with the assigned structure.

Provenance & Evidence