Borane → HCID 86739321, compound

Participants

Reaction Steps

A solution of borane in tetrahydrofuran (1 M, 50 ml) was added carefully to a stirred solution-suspension of 6-chloro-3-cyclohexylcarbonyl-1,2,3,4-tetrahydropyrido[4',3':2,3]indolo[1,7-ab][1,4]benzodiazepin-9(8H)-one (3.0 g) in tetrahydrofuran (100 ml) and the resulting mixture refluxed for 2 hours, cooled and the excess of borane destroyed by dropwise addition of water. The mixture was then evaporated to dryness under reduced pressure and the residue refluxed with a mixture of 1-octene (50 ml) and xylene (80 ml) for 1 hour and xylene and the combined filtrates were evaporated under reduced pressure. The residue was triturated with a small quantity of ether, filtered, and recrystallized from a mixture of 2-propanol and ethanol to yield the title compound, m.p. 230°-233° (dec.).

Provenance & Evidence