N-benzoyl-N'-(2-phenoxyphenyl)thiourea → (2-Phenoxyphenyl)thiourea

HRID 1903730Notes

Reaction equation

HRID 1903730 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][C:15]([NH:17]C(=O)C1C=CC=CC=1)=[S:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[OH-].[Na+].CO>[O:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][C:15]([NH2:17])=[S:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 1488843N-benzoyl-N'-(2-phenoxyphenyl)thiourea

Product 1

HCID 1479735(2-Phenoxyphenyl)thiourea

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
50 °C

Procedure

Thus produced 1-(2-phenoxyphenyl)-3-benzoylthiourea was dissolved in a mixture of 10% aqueous sodium hydroxide (660 ml) and methanol (530 ml) at 50° C. The reaction mixture was stirred for 30 minutes at 50° C. and then cooled with ice to give crystals, which were separated by filtration, washed with water and dried to give 1-(2-phenoxyphenyl)thiourea. mp: 120°-124° C.

Workup

  1. temperaturecooled with ice
  2. customto give crystals, which
  3. customwere separated by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-47b07b30c4a04f77816b46cf4691f90f
Source dataset
uspto-grants-1984_03
Patent number
US04438126

Reaction notes

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