HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-[4-(4-Chlorobenzyloxy)benzyl]thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 2-Bromo-3-[4-(4-chlorobenzyloxy)phenyl]propionic acid | HCID 20462535 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 5-[4-(4-Chlorobenzyloxy)benzyl]thiazolidine-2,4-dione | HCID 12944179 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
In 2 ml of dimethylsulfoxide are dissolved 200 mg of 2-bromo-3-[4-(4-chlorobenzyloxy)phenyl]propionic acid and 100 mg of thiourea and the solution is heated at 110° C. for 3 hours. Then, after 0.5 ml of water is added, the solution is further heated for 5 hours. Then, 10 ml of water is added and the resulting crystals are recovered by filtration and recrystallized from benzene-n-hexane (1:1). By the above procedure is obtained 170 mg of 5-[4-(4-chlorobenzyloxy)benzyl]thiazolidine-2,4-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04438141 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-ba769adc101d40d7934a16d9f19bf33e |
| Source note | uspto-grants-1984_03 |