HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethylhydrazine → 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethylhydrazine | HCID 1322 | — |
| Reactant | Diethyl methylmalonate | HCID 11857 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone | HCID 12818853 | — |
Reaction Steps
Diethyl methylmalonate and N,N'-dimethylhydrazine are heated under reflux for 170 hours in methanol in the presence of sodium methylate under an atmosphere of nitrogen. 3-Hydroxy-1,2,4-trimethyl-5-pyrazolone is obtained in the form of colorless crystals which, after recrystallization from ethyl acetate, melt at 87°-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04438128 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-ac6e86f114b546068b11630d63ef802c |
| Source note | uspto-grants-1984_03 |