HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile → HCID 20237897, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile | HCID 12205687 | — |
| Reactant | 1-[(2-Aminoethyl)amino]-3-phenoxypropan-2-ol | HCID 14550766 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 20237897 | HCID 20237897 | — |
Reaction Steps
5 g. 4-Chloro-5-cyano-1,3-dimethylpyrimidine-2,6(1H,3H)-dione are added in small portions, with cooling, to a solution of 5.26 g. 1-phenoxy-3-(2-aminoethylamino)-propan-2-ol in 20 ml. dimethylformamide. The reaction mixture is stirred for 2 hours at ambient temperature, mixed with 60 ml. isopropyl alcohol, filtered with suction and the solid obtained subsequently washed with isopropyl alcohol. There are obtained 8.7 g. (85% of theory) of the desired product in the form of colorless crystals; m.p. 202°-204° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04438128 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-e5715fe4647740e3ae59b8df6a583710 |
| Source note | uspto-grants-1984_03 |