Ethylenediamine → HCID 178521322, compound

Participants

Reaction Conditions

Reaction Steps

1.22 g. phenyl glycidyl ether and 3.7 g. 1-(2-aminoethylamino)-pyrimido[4,5-d]indole (prepared by reacting 1-chloropyrimido[4,5-b]indole with an excess of ethylenediamine) are stirred for 7 hours at 50° C., in 20 ml. dimethylformamide. The reaction mixture is then evaporated and the residue is purified chromatographically over a silica gel column using, as elution agent, methylene chloride-methanol-triethylamine (10:2:0.3 v/v/v). The residue obtained by evaporation of the pure fractions is mixed in ethyl acetate-ethanol with fumaric acid and the product obtained is recrystallized from ethanol. There is obtained 0.3 g. (15% of theory) of colorless crystals: m.p. 187°-188° C.

Provenance & Evidence