Dimethylformamide → HCID 13304277, compound

Participants

Reaction Steps

2-(2,6-Dichlorophenyl)methylsulfonyl pyridine 1-oxide* (1.75 g, 5.5 mmol) was added in one portion to a stirring solution of 20 mls of dimethylformamide containing 0.24 g of sodium hydroxide and 0.77 g of dimethylsulfate (6.1 mmol). The mixture was allowed to stir at room temperature for 1 h, then poured into 300 ml of rapidly stirring water whereupon a precipitate formed. The precipitate was filtered off, washed with water, and air dried to afford 1.38 g product, m.p. 179°-183° (74% yield).

Provenance & Evidence