化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2,6-Difluoro-alpha-methylbenzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-(2,6-Difluorophenyl)ethan-1-one | HCID 83643 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2,6-Difluoro-alpha-methylbenzyl alcohol | HCID 5012075 | — |
反応手順
2,6-Difluoroacetophenone of (A) (17.2 g, 0.11 mol) is dissolved in isopropyl alcohol (50 ml) and NaBH4 (2.0 g, 0.055 mol) is added. The resultant mixture is warmed to 60° C. for about 14 hours. A solution of NaOH (4.9 g, 0.12 mol) in water (20 ml) is then added. After 1 hour at 60° C., this reaction mixture is cooled and acidified with dilute HCl. Extraction with methylene chloride provided pure title product (14.9 g, 85.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04438271 |
| 出典データセット | uspto-grants-1984_03 |
| ORD ID | ord-0fc9cbc4794842afbb75088d58906529 |
| 出典メモ | uspto-grants-1984_03 |