HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1903831Generated: October 25, 2026
Thionyl Chloride → 2-(1-Chloroethyl)-1,3-difluorobenzene
https://huagongshe.com/reaction/1903831
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,6-Difluoro-alpha-methylbenzyl alcohol | HCID 5012075 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(1-Chloroethyl)-1,3-difluorobenzene | HCID 588055 | 99.8% |
Reaction Steps
2,6-Difluoro-alpha-methylbenzyl alcohol of (B) (14.9 g, 0.094 mol) is dissolved in chloroform (50 ml) and warmed to 60° C. Thionyl chloride (22.4 g, 0.19 mol) is now added dropwise. The whole is kept at 60° C. for 4 hours then stirred overnight at room temperature. Excess thionyl chloride and chloroform are then removed on a rotary evaporator, resulting in pure title product (16.6 g, 99.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04438271 |
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| Source dataset | uspto-grants-1984_03 |
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| ORD ID | ord-05eb1a4e6dd5472fb76ab7ef7c7bbbc6 |
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| Source note | uspto-grants-1984_03 |
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