反应详情

温度

75 °C

2,6-Difluoro-alpha-methylbenzyl chloride (16.6 g, 0.094 mol) is dissolved in ethanol (40 ml) and warmed to 75° C. A 40 percent solution of sodium omadine (38.5 g, 0.103 mol) is added dropwise over a period of 30 minutes maintaining a reaction temperature of 75° C. throughout. Once the addition is complete, the reaction mixture is kept between 75° C. and 80° C. for 2 hours. Thereafter the mixture is quenched in ice-water and crude product is filtered off. After recrystallization with ethyl acetate pure title product (10.65 g, 42.4%) is obtained; Melting Point 158°-160° C.

1. temperaturemaintaining a reaction temperature of 75° C. throughout
2. additionOnce the addition
3. customThereafter the mixture is quenched in ice-water
4. filtrationcrude product is filtered off
5. customAfter recrystallization with ethyl acetate pure title product (10.65 g, 42.4%)
6. customis obtained