HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-6-fluoro-alpha-methylbenzyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(2-Chloro-6-fluorophenyl)ethan-1-ol | HCID 13304279 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Chloro-6-fluoro-alpha-methylbenzyl chloride | HCID 13304280 | 92.6% |
Reaction Steps
2-chloro-6-fluoro-alpha-methylbenzyl alcohol of (B) (45.1 g, 0.26 mol) is dissolved in chloroform (70 ml), and thionyl chloride (61.5 g, 0.52 mol) is added over a period of 30 minutes. The resultant mixture is refluxed for 16 hours. Excess thionyl chloroform are then removed on a rotary evaporator, resulting in pure title product (46.2 g, 92.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04438271 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-9ba5eb5e56164fd0b121fc1ed44dfc6d |
| Source note | uspto-grants-1984_03 |