HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → HCID 131712173, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- | HCID 77857 | — |
| Reactant | HCID 22815435 | HCID 22815435 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131712173 | HCID 131712173 | — |
Reaction Steps
2.9 g of Boc-Phe-OH and 1.4 ml of N-ethyl-morpholine are dissolved in 50 ml of absolute tetrahydrofuran and 1.4 ml of chloroformic acid iso-butyl ester added at -10°. After 10 minutes, a solution of 1.7 g of methioninol-hydrochloride in 25 ml of dimethyl formamide is added. After two hours stirring at room temperature, the solution is evaporated under vacuum and the residue taken up in acetic acid. The solution is repeatedly washed with dilute citric acid and potassium bicarbonate and the title compound isolated. M.P. 106°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04438103 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-aa48b795838a4c07a99548fe7a5d8131 |
| Source note | uspto-grants-1984_03 |