Sodium Hydroxide → HCID 13290545, compound

HRID 1903878Notes

Reaction equation

HRID 1903878 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:21]=[CH:20][C:10]([O:11][CH:12]([CH2:18][CH3:19])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=2)[C:5]2[CH:22]=[CH:23][C:24]([C:26]([F:29])([F:28])[F:27])=[CH:25][C:4]=2[N:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[N:6]([C:7]2[CH:21]=[CH:20][C:10]([O:11][CH:12]([CH2:18][CH3:19])[C:13]([OH:15])=[O:14])=[CH:9][CH:8]=2)[C:5]2[CH:22]=[CH:23][C:24]([C:26]([F:29])([F:28])[F:27])=[CH:25][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13290541HCID 13290541, compound

Product 1

HCID 13290545HCID 13290545, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4.0 g of 6 and 0.4 g of sodium hydroxide in 50 ml of 50% ethanol was refluxed for 45 minutes, then concentrated to dryness. The residue was mixed with water, the mixture was acidified with hydrochloric acid and extracted with ether. The ether was evaporated from the extract and the residue was recrystallized from ether-hexane to give 8, as a white solid, m.p.: 98° C.

Workup

  1. temperaturewas refluxed for 45 minutes
  2. concentrationconcentrated to dryness
  3. additionThe residue was mixed with water
  4. extractionextracted with ether
  5. customThe ether was evaporated from the
  6. extractionextract
  7. customthe residue was recrystallized from ether-hexane
  8. customto give 8

Sources & evidence

ORD record
ord-b64a18f24a994497a0c36939a0b0f020
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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