Sodium Hydroxide → HCID 13290547, compound

HRID 1903882Notes

Reaction equation

HRID 1903882 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:21]=[CH:20][C:10]([O:11][CH:12]([CH2:17][O:18][CH3:19])[C:13]([O:15]C)=[O:14])=[CH:9][CH:8]=2)[C:5]2[CH:22]=[CH:23][C:24]([C:26]([F:29])([F:28])[F:27])=[CH:25][C:4]=2[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][C:10]([O:11][CH:12]([CH2:17][O:18][CH3:19])[C:13]([OH:15])=[O:14])=[CH:20][CH:21]=2)[C:5]2[CH:22]=[CH:23][C:24]([C:26]([F:29])([F:27])[F:28])=[CH:25][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13290549HCID 13290549, compound

Product 1

HCID 13290547HCID 13290547, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4.5 g of 10 and 0.5 g of sodium hydroxide in 50 ml of aqueous methanol was refluxed for 2 hours. The resulting mixture was concentrated to dryness, the residue was acidified with dilute hydrochloric acid and extracted with ether. The extract was dried and concentrated. The residue was crystallized from ether-hexane to give 11, as a light tan crystalline solid, m.p.: 111°-112° C.

Workup

  1. concentrationThe resulting mixture was concentrated to dryness
  2. extractionextracted with ether
  3. customThe extract was dried
  4. concentrationconcentrated
  5. customThe residue was crystallized from ether-hexane

Sources & evidence

ORD record
ord-188dbcdec247472aaad38690c78b67ad
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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