HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-(3-Amino-4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1H-Isoindole-1,3(2H)-dione, 2-(4-chloro-3-nitrophenyl)-4,5,6,7-tetrahydro- | HCID 156879 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(3-Amino-4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide | HCID 13285967 | 80.4% |
Reaction Steps
To a solution of 40 g of N-(3-nitro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide in 900 ml. of MeOH and 100 ml. of EtOAc in a hydrogenation bottle is added 0.5 g PtO2. The bottle is purged with hydrogen then pressurized to 50 psig and shaken until the required amount of H2 was used. The reaction mixture was filtered through celite, washed well with CH2Cl2 and the combined organic phases concentrated in vacuo to yield 29 g of the product. This product was used without further purification in subsequent transformations.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04439229 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-6274814401c3424bb806403038c81f40 |
| Source note | uspto-grants-1984_03 |