Acetic Acid → HCID 13288068, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4.4 g (0.11 mole) of sodium hydroxide in 350 ml of water was added 3.0 g (0.047 mole) of ethyl 5-amino-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylate (Example 1). The resulting slurry was stirred at about 90° C. for three hours, then cooled to room temperature and neutralized with 9.3 ml of acetic acid. The solid product was collected by filtration and recrystallized from dimethylformamide to give 10.3 g of 5-amino-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid, colorless crystals, m.p. 309°-313° C. (decompn.).

Provenance & Evidence