Water → HCID 13288075, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.6 g (0.0132 mole) of ethyl 5,8-dihydro-5-[(methoxycarbonyl)methylamino]-8-oxo-1,3-dioxolo[4,5-g]-quinoline-7-carboxylate (Example 5), 1.6 g (0.0396 mole) of sodium hydroxide and about 100 ml of water was stirred at 95° C. for 4.5 hours. The reaction mixture was cooled, acidified with 5 ml of acetic acid with stirring, and kept in a refrigerator overnight. The solid product was collected by filtration, washed with water and recrystallized from 70 ml of boiling dimethylformamide. There was obtained 3 g of 5,8-dihydro-5-(methylamino)-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid, colorless crystals, m.p. above 300° C.

Provenance & Evidence