Potassium Hydroxide → HCID 13288076, compound

Participants

Reaction Steps

To a suspension of 4.1 g (0.013 mole) of ethyl 5,8-dihydro-5-[(formyl)methylamino]-8-oxo-1,3-dioxolo[4,5-g]-quinoline-7-carboxylate (Example 6) in 40 ml of hot absolute ethanol was added a solution of 0.8 g (0.013 mole) of potassium hydroxide (85%) in 2.6 ml of water. The mixture was heated at near the boiling point of the ethanol for about 10 minutes and then chilled in an ice bath. The solid product was collected by filtration and washed with absolute ethanol and ether. After a further washing with water, tetrahydrofuran and ether and drying at 0.1 mm overnight there was obtained 3.1 g of ethyl 5,8-dihydro-5-(methylamino)-8-oxo-1,3-dioxolo[4,5-g]-quinoline-7-carboxylate, colorless crystals, m.p. 211°-218° C.

Provenance & Evidence