Potassium Hydroxide → HCID 13288078, compound

Participants

Reaction Steps

To a stirred suspension of 2 g (0.006 mole) of ethyl 5-[ethyl(formyl)amino]-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]-quinoline-7-carboxylate (Example 8) in 53.8 ml of refluxing ethanol was added a solution of 0.9 g (0.014 mole) of potassium hydroxide in 3 ml of water over a period of about two minutes. After a few more minutes of reflux, 30 ml of additional ethanol was added and reflux continued for one hour. The reaction mixture was allowed to stand overnight, then chilled in an ice-bath, and the solid product was collected by filtration and washed with absolute alcohol and ether to give 2 g of 5-(ethylamino)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid in the form of its potassium salt hemihydrate, m.p. 242° C. (decompn.) after being dried for several days at 75° C. (0.1 mm).

Provenance & Evidence