HCID 19852896, compound → HCID 20465905, compound

Participants

Reaction Steps

51.5 g of the above-prepared 4-isopropoxycarbonylphenyl isocyanate were added to a solution of 61.9 g of 3-(4-chlorophenyl)-4-(3-cyanopropyl)-2-pyrazoline in 450 ml of diethyl ether at room temperature. After stirring for 30 minutes at room temperature, 500 ml of petroleum ether (40-60) were added, after which the reaction mixture was stirred at room temperature for another hour. The crystalline precipitate was sucked off, washed with petroleum ether (40-60) and dried in air. 95.0 g Of 1-(4-isopropoxycarbonylphenylcarbamoyl)-3-(4-chlorophenyl)-4-(3-cyanopropyl)-2-pyrazoline were obtained. After stirring 10 g of the resulting product with 100 ml of diethyl ether, a product was obtained having a melting point of 109°-113° C.

Provenance & Evidence