Sodium Hydroxide → HCID 53912996, compound

Participants

Reaction Steps

In 10 ml of methanol was suspended 1.68 g (0.005 mole) of N-[4-(1-ethoxycarbonyl-n-propyl)phenyl]-L-glutamine and a solution of 0.42 g of sodium hydroxide in 20 ml of water was added thereto and stirred for 1.5 hours at room temperature. The solvent was then distilled off in vacuo to about a half volume and the remaining solution was acidified to pH 4 with 5% hydrochloric acid. The precipitated crystals were collected by filtration, washed with cold water and dried in vacuo to give 1.16 g (0.0038 mole, 75% yield) of N-[4-(1-carboxy-n-propyl)phenyl]-L-glutamine, m.p. 166.5°-167.0° C.

Provenance & Evidence