2-Methoxy-4-nitroaniline → HCID 53732734, compound

Participants

Reaction Steps

8.3 g of 2-methoxy-4-nitroaniline was diazotized in a conventional manner using 4 g of sodium nitrite. The diazotized solution thus obtained was added to a mixture composed of 12 g of 3-acetylamino-N-ethyl-N-hydroxyethylaniline, 20 g of sodium acetate, 70 ml of methyl Cellosolve and 50 ml of water at a temperature of not more than 10° C. The mixture was stirred at a temperature range between 10° C. and 15° C. for 30 minutes, the crystals thus deposited were collected by filtration and washed with water. The crude product was recrystallized from acetonitrile to obtain 16 g of Compound [1-g].

Provenance & Evidence