HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Z-Ser(But)-Ser(But)-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Z-Ser(tBu)-OH | HCID 1715617 | — |
| Reactant | (S)-Methyl 2-amino-3-(tert-butoxy)propanoate | HCID 7018830 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Ser(But)-Ser(But)-OMe | HCID 131713446 | — |
Reaction Steps
To 4.43 g of Z-Ser(But)-OH and 3.18 g of HCl.H-Ser(But)-OMe in 30 ml of dimethylformamide are added at 0° 1.89 ml of N-ethylmorpholine, 2.29 g of HOBt and 3.4 g of dicyclohexylcarbodiimide. After standing for 2 hours at 0° and for 15 hours at 20°, the resulting product is filtered off, the filtrate is concentrated by evaporation and taken up in ethyl acetate. After extraction of the solution with sodium bicarbonate, dilute hydrochloric acid and water, the solution is concentrated by evaporation to leave as oil Z-Ser(But)-Ser(But)-OMe; Rf (toluene/acetone 1:1)=0.70.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04439425 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-648a931901cb4480963112ae3a3deab9 |
| Source note | uspto-grants-1984_03 |