Hydrochloric Acid → (2S)-2-amino-N-[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-phenylpropanamide

Participants

Reaction Steps

The hydrochloride named above can be prepared in the following manner: 4.62 g of Z-Phe-Tyr-NH2 are hydrogenated in 50 ml of methanol in the presence of 4 ml of hydrochloric acid in methanol (2.53 N) and 0.5 g of palladium-carbon (10%). After filtering the catalyst and evaporating the filtrate the HCl.H-Phe-Tyr-NH2 is obtained as a white foam. Rf-value on silicagel (with chloroform-methanol) is 0.42.

Provenance & Evidence