HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloro-2-isocyanatobenzene → N-(2,6-Dichlorophenyl)-4-(pyrazin-2-yl)piperazine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloro-2-isocyanatobenzene | HCID 604537 | — |
| Reactant | 1-Piperazinylpyrazine | HCID 2734639 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-(2,6-Dichlorophenyl)-4-(pyrazin-2-yl)piperazine-1-carboxamide | HCID 13298546 | — |
Reaction Steps
A solution of 1.88 g. of 2,6-dichlorophenylisocyanate in 25 ml. of anhydrous ether was added dropwise to a stirred solution of 1.64 g. of 1-(2-pyrazinyl)piperazine in 250 ml. of anhydrous ether. The mixture was stirred for 30 minutes and the solid was collected and recrystallized from ethanol, giving 3.12 g. of the desired product, m.p. 177°-179° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04439606 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-387d87fc2b2c439bb66dbbd8b8090842 |
| Source note | uspto-grants-1984_03 |