Sulfuric Acid → 2-Amino-2,3-dimethylbutanamide

HRID 1904061Notes

Reaction equation

[NH2:1][C:2]([CH3:8])([CH:5]([CH3:7])[CH3:6])[C:3]#[N:4].S(=O)(=O)(O)[OH:10]>>[NH2:1][C:2]([CH3:8])([CH:5]([CH3:7])[CH3:6])[C:3]([NH2:4])=[O:10]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 943552-Amino-2,3-dimethylbutyronitrile

Product 1

HCID 97937732-Amino-2,3-dimethylbutanamide

Procedure

In a similar way, hydrolysis of the (+)-2-amino-2,3-dimethylbutyronitrile with sulfuric acid yields (+)-2-amino-2,3-dimethylbutyramide, mp 74.5°-76° C.

Sources & evidence

ORD record: ord-866d100826344124be2f474acdcd732e
Source dataset: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04439607

Reaction notes

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