反应详情

温度

-70 °C

A steel bomb was charged with liquid ammonia (60 ml) with cooling in an isopropanol-dry ice bath maintained at -70° C. The epoxide (III) (21.46 g, 0.15 mole) was added to it, followed by water (2.70 ml, 0.15 mole). The bomb was sealed and, then, heated in an oil bath at 120° for 4 hr. The bomb was cooled, opened and the ammonia was allowed to evaporate. The crude residue was triturated with ether, chilled, and the crystalline product was isolated by filtration. The amine (IV) was obtained as white prisms. (18.78 g, yield 87%). m.p. 81.5°-82.5°.

1. temperaturewith cooling in an isopropanol-dry ice bath
2. customThe bomb was sealed
3. temperatureheated in an oil bath at 120° for 4 hr
4. temperatureThe bomb was cooled
5. customto evaporate
6. customThe crude residue was triturated with ether
7. temperaturechilled
8. customthe crystalline product was isolated by filtration