HCID 178521058, compound → HCID 53633108, compound

HRID 1904117Notes

Reaction equation

HRID 1904117 reaction equation
[C@@H:1]1([N:10]2[C:14]3[N:15]=[CH:16][NH:17][C:18](=S)[C:13]=3[CH:12]=[CH:11]2)[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]>[Ni].O>[C@@H:1]1([N:10]2[C:14]3[N:15]=[CH:16][N:17]=[CH:18][C:13]=3[CH:12]=[CH:11]2)[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]

Participants

4

Reactant 1

HCID 178521058HCID 178521058, compound

Product 1

HCID 53633108HCID 53633108, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 962WaterSolvent

Procedure

A mixture of 5 g of 7-β-D-arabinofuranosyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-thione, 5 g of Raney nickel, and 250 ml of water is stirred and heated under reflux for one hour and filtered while hot. The filtrate is evaporated in vacuo to a small volume and cooled to provide pure 7-β-D-arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine.

Workup

  1. temperatureheated
  2. temperatureunder reflux for one hour
  3. filtrationfiltered while hot
  4. customThe filtrate is evaporated in vacuo to a small volume
  5. temperaturecooled

Sources & evidence

ORD record
ord-8ebc9ff72d0e481cafd9035588cf905f
Source dataset
uspto-grants-1984_03
Patent number
US04439604

Reaction notes

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