Hydrochloric Acid → HCID 131713451, compound

Participants

Reaction Steps

A mixture of 0.085 g of the product of Step B, 0.12 g of bromomethyl phthalimide, 0.069 g of potassium carbonate and 0.4 ml of dimethylsulfoxide was vigorously stirred for 15 minutes at room temperature and 10 ml of 0.1 N hydrochloric acid were added thereto. The mixture was vacuum filtered and the product was washed with water and dried to obtain 0.124 g of raw product. The latter was dissolved in 1 ml of ethyl acetate and the solution was treated with activated carbon and the solvent was distilled off. The residue was efflorescenced with ether and the mixture was vacuum filtered to obtain 0.075 g of syn isomer of diphenylmethyl 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-phthalimidomethyloxyimino-acetamido]-ceph-3-eme-4-carboxylate.

Provenance & Evidence