Sodium Acetate → HCID 131713454, compound

Participants

Reaction Steps

A solution of 0.283 g of the product of Example 8, 1 ml of 1 M sodium acetate in methanol and 1 ml of methanol was treated with 30 g of activated carbon and the mixture was filtered. The filter was rinsed 3 times with methanol and the filtrate was evaporated under reduced pressure at a temperature less than 30° C. to a volume of 1 ml. The solution was diluted with 10 ml of ethanol at 100° C. and was vacuum filtered. The mixture was rinsed with 100° C. ethanol and then with ether to obtain 0.165 g of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-(2-oxo-3-tetrahydrofuranyloxyimino)-acetamido]-ceph-3-eme-4-carboxylate.

Provenance & Evidence